Aging of the Liver
Aging is understood as a normal progressive decline in body functions that, cumulatively, diminish a cell or organ capacity to respond to intrinsic or extrinsic stimuli. Most people commonly think that all body functions decline with aging, but the liver however adapts to aging and has a constant function. Diseases found within the liver in a usual cause for mortality. Liver disease related mortality is known to affect person who are between the ages of 45 to 85.
Aging of the liver is related to an aging population, because its survival curve shows a linear decrease with time. Figure 1 on page 2 is a death rate caused by chronic liver disease and cirrhosis in California. Because dx, or death rate, increases with age, this symbolizes liver diseases caused by changes in structure and function is an age-related case. This leads to decrease in further expectation of life, or ex, with increasing age. (pg. 32 from textbook)
Figure 5 on page 2 represents cytochrome p45 concentration with increasing age. As you can see, there is a decrease in concentration with increasing age. But, that is the mean, which represents the population. There are circles everyone on the graph. These circles represent individual cases. Some are close to the mean line, while others are way off. Individually, being at a specific age doesn't guarantee you will have a cytochrome concentration to that of the mean value.
Aging of the liver can be tied to evolutionary theories because it can become a useful tool to explore new reasons and future studies along with testable predictions of why aging of the liver occurs. For instance the concept underlying evolutionary theory of aging suggests that the Natural environment is hazardous. Can the effect of the atmosphere also aid, the process of aging liver? A natural effect done by the body is the age-related decline in bile salt
secretion, coupled with the increase in cholesterol secretion, is a concomitant decline in bile salt...