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Using the Scale for Assessment of Negative Symptoms (Sans) as an Outcome Measure, Does Amisulpride Improve Negative Symptoms for Adults with Chronic Schizophrenia Compared to Placebo over a One Year Timeframe? Essay

  • Submitted by: megrobertson
  • on October 19, 2013
  • Category: Miscellaneous
  • Length: 1,021 words

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Below is an essay on "Using the Scale for Assessment of Negative Symptoms (Sans) as an Outcome Measure, Does Amisulpride Improve Negative Symptoms for Adults with Chronic Schizophrenia Compared to Placebo over a One Year Timeframe?" from Anti Essays, your source for research papers, essays, and term paper examples.

Assessment 2
Using the scale for assessment of negative symptoms (SANS) as an outcome measure, does amisulpride improve negative symptoms for adults with chronic schizophrenia compared to placebo over a one year timeframe?

Meg Robertson
Mental Health
Single Point of Entry to Mental Health

The question stated is relevant to my practice as those living with schizophrenia identify negative symptoms as the most disabling aspect of the disease (1) and limited research has been conducted on the possibility of pharmacological treatment for negative symptoms (2)
The dopamine hypothesis as the biological cause of schizophrenia (3) states certain neuronal pathways in the brain become overactive through excess dopamine release (4).   Mesolimbic pathway over stimulation via excessive dopamine is thought to be responsible for the positive symptoms of schizophrenia.   The negative symptoms of schizophrenia may be caused by reduction of dopamine in the prefrontal cortex (PFC), which is responsible for executive functioning (5). Many traditional antipsychotic drugs perpetuate negative symptoms by blocking receptors in the PFC, further lowering dopamine levels there (6).
Attempts to negate the side effects of traditional antipsychotic medication resulted in target receptor specify, reducing the positive symptoms of schizophrenia while negating many EPS side effects (3).   Amisulpride was discovered to have a unique feature in that in that it has a pro-dopamine effect in the prefrontal cortex (6).   D2 auto-receptors are blocked in the synaptic cleft of the PFC, dopamine is prevented from re-entering the pre-synaptic cell; there is more dopamine available in the synaptic cleft for uptake by the post synaptic cell.   Dopamine is increased in the PFC causing an improvement in negative symptoms (7).

A 2013 amisulpride versus placebo RCT was conducted by Leucht et al, n=383.   This one year trial used symptom remission as defined by SANS as the outcome measure.   No participants...

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MLA Citation

"Using the Scale for Assessment of Negative Symptoms (Sans) as an Outcome Measure, Does Amisulpride Improve Negative Symptoms for Adults with Chronic Schizophrenia Compared to Placebo over a One Year Timeframe?". Anti Essays. 15 Dec. 2018

<http://parimatch-stavka7.com/free-essays/Using-The-Scale-For-Assessment-Of-529307.html>

APA Citation

Using the Scale for Assessment of Negative Symptoms (Sans) as an Outcome Measure, Does Amisulpride Improve Negative Symptoms for Adults with Chronic Schizophrenia Compared to Placebo over a One Year Timeframe?. Anti Essays. Retrieved December 15, 2018, from the World Wide Web: http://parimatch-stavka7.com/free-essays/Using-The-Scale-For-Assessment-Of-529307.html


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