1Beerepoot, M., Ter Riet, G., Nys, S., WM, de Borgie, C., de Reijke, T., & ... Geerlings, S. (2011). Cranberries vs Antibiotics to Prevent Urinary Tract Infections: A Randomized Double-blind Noninferiority Trial in Premenopausal Women. Archives Of Internal Medicine, 171(14), 1270-1278. doi:10.1001/archinternmed.2011.306
In this article, the researchers were interested in novel nonantibiotic methods for the prevention of urinary tract infections. The researchers conducted a double-blind, double-dummy, they recruited 221 premenopausal women with recurrent UTIs: 110 were randomized to antibiotics and 111 to cranberries. They compared 12 months' prophylaxis use with either antibiotics, 480 mg once daily, or cranberry capsules, 500 mg twice daily, for the prevention of rUTI. The researchers looked at E. coli isolates because it is the most stubborn bacteria in UTI.
After discontinuation of the study medication, after 12 months or earlier in case of dropout, women were asked to guess to which intervention they had been assigned (antibiotic, cranberries, or don't know). In the number of clinical recurrences (CR), meaning, those woman who complained of UTI symptoms subjectively, the woman who had been on the cranberry pills had shown more recurrences than those on the antibiotics. In the percentage of woman who were free of clinical recurrences, the percentage was higher for those on the antibiotic prophylaxis than those on the cranberry pill. With this information, it safe to assume that the use of antibiotics is more effective at killing E. coli to prevent UTI recurrences, than the use of cranberries as a nonantibiotic method.
2Deepalatha, C. C., & Deshpande, N. (2011). A COMPARATIVE STUDY OF PHENAZOPYRIDINE (PYRIDIUM) AND CYSTONE AS SHORT-TERM ANALGESIC IN UNCOMPLICATED URINARY TRACT INFECTION. International Journal Of Pharmacy & Pharmaceutical Sciences, 3224-226.
In this study, researchers wanted to show if the OTC drug PHENAZOPYRIDINE (brand name...